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Protection of the commercially available hydro ester 22 with tertiary-butyldimethylsilyl chloride TBDMS-Cl gave silyl ester 23.

The ester 23 on reduction with Li BH4 gave the alcohol.

Alcohol 26 was treated with 2-methoxy propene and pyridinium p-toluenesulfonate PPTS to generate protected diol 27. desferrioxamine B, fosmidomycin, siderophores 28 and allergic diseases. 29 The wide biological application of hydroxamates necessitates the review of its synthesis and biological applications. General Synthesis of Weinreb Amides Hydroxamic acids are prepared usually from esters or acid chlorides or carboxylic acids.2.1. Hyper acetylation of histones increases the access of some transcription factors to nucleosomes thereby increasing RNA transcription. Histone deacetylase inhibitors HDI leads to hyper acetylation by blocking the function of histone deacetylase, therefore leaving the lysine amino acids acetylated from the histone acetyl transferase and ultimately increasing transcription.